This article explores the pathophysiological mechanisms underlying the development of hypertension, with a special emphasis on the hormonal factors that contribute to elevated blood pressure. Hypertension, one of the most prevalent cardiovascular disorders worldwide, results from a complex interplay between genetic predisposition, environmental influences, and dysregulation of multiple physiological systems. The article discusses how alterations in renal function, vascular resistance, and sympathetic nervous system activity lead to chronic elevation of arterial pressure. Particular attention is given to the renin-angiotensin-aldosterone system (RAAS), vasopressin, and other endocrine factors such as catecholamines and natriuretic peptides. The review also highlights the feedback loops and receptor sensitivities that sustain hypertensive states over time. Understanding these hormonal contributions is essential for identifying therapeutic targets and improving the management of hypertensive patients. Overall, the paper aims to provide a comprehensive view of how hormonal imbalance acts as a key driver in the pathogenesis of hypertension.

Bul maqalada emocional sharshaw sindromı (burnout) túsinigi, onıń qáliplesiw sebepleri hám ásirese, sociallıq belsendilik penen baylanıslı júzege keletuǵın psixologiyalıq hám fiziologiyalıq qáwip-qáterler tallanǵan. Sonday-aq, sindromnıń aldın alıw boyınsha usınıslar da berilgen.

Mazkur maqola, toshkent viloyаti xаlq xo‘jаligidа temir yo‘llаr tizimining o‘rni mavzusida yozilgan. Ushbu maqolada, toshkent viloyаti xаlq xo‘jаligidа temir yo‘llаr tizimining o‘rni va xususiyatlari o‘rganilgan. Maqolada toshkent viloyаti xаlq xo‘jаligidа temir yo‘llаr tizimining o‘rni samarali bo‘lishi va ularning yuqori natijalarga erishishi uchun qanday shart-sharoitlar zarurligi tahlil qilingan.

Surxon vohasida esa Sherobod, Denov, Boysun, Sarijo’y va Yurchi kabi bekliklar bo’lgan va bular turli davrlarda tashkil etilib yugatilib turilgan. Ushbu maqolada esa Surxon vohasining shimoliy qismida joylashgan bekliklarni tadqiq qilamiz.

This paper explores the physiological and pathophysiological responses of the human body to stress. Stress, defined as any challenge that disrupts homeostasis, triggers complex mechanisms involving the nervous, endocrine, and immune systems. Acute stress activates adaptive responses, such as the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, which prepare the body to handle immediate threats. However, chronic stress leads to sustained hormonal imbalances, immune suppression, and increased inflammation, contributing to various diseases including cardiovascular disorders, diabetes, and mental health issues. The dual nature of stress highlights the importance of effective management strategies to maintain health and prevent disease progression. This paper also discusses current understanding of stress-immune system interactions and suggests holistic approaches for stress reduction and health improvement.