This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.

Agar kishi biror bir og‘ir ishni bajarayotgan bo‘lsa, u birmuncha vaqtdan so‘ng bu ishni bajarish tobora qiynlashib borayotganini sezadi. Chetdan qaraganda bu kishining holati ancha o‘zgarganligini ko‘rish mumkin. Bu o‘zgarishni mimika muskullari kuchlanishida, ter paydo bo‘lishida kurish mumkin.ayni vaqtda uning organizmida bimruncha jiddiy fiziologik o‘zgarishlar ham ro‘y beradi. Qiyinchiliklar ko‘payib borishiga karamsdan, kishi iroda kuchi hisobiga dastlabki ish shiddati birmuncha vaqt saqlab turishi mumkin.

This article explores the pathophysiological mechanisms underlying the development of hypertension, with a special emphasis on the hormonal factors that contribute to elevated blood pressure. Hypertension, one of the most prevalent cardiovascular disorders worldwide, results from a complex interplay between genetic predisposition, environmental influences, and dysregulation of multiple physiological systems. The article discusses how alterations in renal function, vascular resistance, and sympathetic nervous system activity lead to chronic elevation of arterial pressure. Particular attention is given to the renin-angiotensin-aldosterone system (RAAS), vasopressin, and other endocrine factors such as catecholamines and natriuretic peptides. The review also highlights the feedback loops and receptor sensitivities that sustain hypertensive states over time. Understanding these hormonal contributions is essential for identifying therapeutic targets and improving the management of hypertensive patients. Overall, the paper aims to provide a comprehensive view of how hormonal imbalance acts as a key driver in the pathogenesis of hypertension.

Psixologiyalıq másláhát degen ne, ol qanday, shólkemlestiriliwi hám alıp barılıwı haqqındaǵı tiykarǵı, keń kólemli hám túsinikli bayanlanǵan maǵlıwmatlar haqqında túsinik berilgen.

Mazkur maqolada jismoniy tarbiya va sport sohasida raqamli texnologiyalarning qo‘llanilishiga oid yangi tendensiyalar, ularning samaradorligi va imkoniyatlari tahlil qilinadi. Axborot-kommunikatsiya texnologiyalarining jadal rivojlanishi sport mashg‘ulotlarini takomillashtirish, sportchilarning salomatligini monitoring qilish, trening jarayonlarini optimallashtirish hamda sport tadbirlarini keng auditoriyaga yetkazishda muhim ahamiyat kasb etmoqda.