This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.

This theoretical research explores the economic views of Abdurauf Fitrat, a prominent Central Asian thinker, by comparing them with his contemporaries and interpreting them through a modern lens. Fitrat's ideas reflect a synthesis of Islamic economic principles and modernist thought. By conducting a comparative analysis with regional and global economic thinkers of his time, this paper aims to highlight the unique aspects of his vision. The study uses a descriptive-analytical method and draws on primary texts, archival material, and secondary scholarly interpretations.

Surxon vohasida esa Sherobod, Denov, Boysun, Sarijo’y va Yurchi kabi bekliklar bo’lgan va bular turli davrlarda tashkil etilib yugatilib turilgan. Ushbu maqolada esa Surxon vohasining shimoliy qismida joylashgan bekliklarni tadqiq qilamiz.

Ushbu maqolada XIX asr oxiri va XX asr boshlarida O‘rta Osiyoda yuzaga kelgan jadidchilik harakatining mazmun-mohiyati, tarixiy bosqichlari, asosiy g‘oyalari hamda bugungi kunda bu harakat merosining O‘zbekiston jamiyatidagi ahamiyati tahlil qilinadi. Jadidchilik harakatining asoschilari tomonidan ilgari surilgan ma’rifiy, ijtimoiy va siyosiy g‘oyalarning zamonaviy ta’lim tizimi, gender tengligi, milliy o‘zlikni anglash va fuqarolik jamiyati qurilishiga ta’siri yoritilgan. Shuningdek, jadid matbuoti, teatr va adabiy merosining yosh avlod tarbiyasidagi roli, bugungi islohotlar bilan o‘zaro bog‘liqligi chuqur o‘rganilgan. Maqolada tarixiy va zamonaviy qarashlar uyg‘unligi orqali jadidchilik harakatining dolzarbligi va bugungi kundagi o‘rni ilmiy asosda tahlil etiladi.

Ushbu maqola Mirzo Ulug'bekning iqtisodiy va ilmiy merosini tangalar zarbi orqali yoritishga bag‘ishlangan. Ulug'bek O‘rta Osiyo tarixidagi yirik olim va hukmdor sifatida nafaqat astronomiya va matematika sohalarida, balki iqtisodiy rivojlanishda ham muhim rol o‘ynagan.Ushbu maqola Mirzo Ulug'bekning iqtisodiy va ilmiy merosini tangalar zarbi orqali yoritishga bag‘ishlangan. Ulug'bek O‘rta Osiyo tarixidagi yirik olim va hukmdor sifatida nafaqat astronomiya va matematika sohalarida, balki iqtisodiy rivojlanishda ham muhim rol o‘ynagan.