This article explores the complex pathophysiological mechanisms underlying the development of kidney failure. It highlights the key roles of hemodynamic changes, cellular injury, inflammation, oxidative stress, and hormonal imbalances in the progression of renal dysfunction. The chronic activation of the renin-angiotensin-aldosterone system and its contribution to fibrosis and nephron loss are discussed in detail. The article also examines how inflammatory processes and oxidative damage exacerbate kidney tissue injury, while hormonal disturbances contribute to systemic complications such as anemia and mineral imbalance. Emphasis is placed on the importance of early detection and targeted treatment strategies to slow disease progression and improve patient outcomes. The review concludes with a discussion on future research directions aimed at developing novel diagnostic markers and therapeutic approaches for kidney failure.

This article discusses the issues of managing energy sources in modern communication systems through adaptive control models to improve energy efficiency. The possibility of evaluating the energy supply state in real-time, considering the variability of the load and external factors, and developing optimal control strategies is analyzed.

Mazkur maqolada sport tadbirlarida marketing strategiyalarining tutgan o‘rni, ularning qo‘llanilish shakllari va samaradorlik darajasi har tomonlama tahlil qilinadi. Sport sohasi zamonaviy jamiyatda nafaqat sog‘lom turmush tarzini targ‘ib qiluvchi ijtimoiy institut, balki katta iqtisodiy salohiyatga ega bo‘lgan tarmoq sifatida ham maydonga chiqmoqda. Xususan, yirik sport tadbirlarining muvaffaqiyatli tashkil etilishi ularning marketing jihatdan to‘g‘ri rejalashtirilganligiga bog‘liq. Maqolada sport marketingining asosiy strategiyalari — brending, raqamli marketing, homiylik aloqalari, auditoriya bilan ishlash va tomoshabinlar tajribasini boshqarish kabi yo‘nalishlar alohida ko‘rib chiqiladi.

Usı maqalada psixologiyalıq keńes túsinigi, onıń mazmunı, ámeliy áhmiyeti hám de psixologiya pánindegi ózine tán mashqala sıpatında úyreniliwi jaritılǵan. Sonday-aq, másláhátlesiw procesiniń basqıshları, psixologiyalıq qatnaslar hám qarıydar menen islesiwde júzege keletuǵın qıyınshılıqlar da tallanǵan.

Agar kishi biror bir og‘ir ishni bajarayotgan bo‘lsa, u birmuncha vaqtdan so‘ng bu ishni bajarish tobora qiynlashib borayotganini sezadi. Chetdan qaraganda bu kishining holati ancha o‘zgarganligini ko‘rish mumkin. Bu o‘zgarishni mimika muskullari kuchlanishida, ter paydo bo‘lishida kurish mumkin.ayni vaqtda uning organizmida bimruncha jiddiy fiziologik o‘zgarishlar ham ro‘y beradi. Qiyinchiliklar ko‘payib borishiga karamsdan, kishi iroda kuchi hisobiga dastlabki ish shiddati birmuncha vaqt saqlab turishi mumkin.