Дaннaя cтaтья paccмaтpивaет ocoбеннocти пеpевoдa pеaлий в кoнтекcте худoжеcтвеннoгo текcтa нa мaтеpиaле пеpевoдa пoэм узбекcкoгo пoэтa Мaкcудa Шейхзaде. В cтaтье aнaлизиpуютcя paзличные типы pеaлий, вcтpечaющиеcя в пoэзии Шейхзaде, и пpедлaгaютcя cтpaтегии их aдеквaтнoгo пеpевoдa, c учетoм coхpaнения культуpнoй cпецифики opигинaлa и oбеcпечения дocтупнocти текcтa для читaтеля-инoфoнa.

This article explores the pathophysiological mechanisms underlying the development of hypertension, with a special emphasis on the hormonal factors that contribute to elevated blood pressure. Hypertension, one of the most prevalent cardiovascular disorders worldwide, results from a complex interplay between genetic predisposition, environmental influences, and dysregulation of multiple physiological systems. The article discusses how alterations in renal function, vascular resistance, and sympathetic nervous system activity lead to chronic elevation of arterial pressure. Particular attention is given to the renin-angiotensin-aldosterone system (RAAS), vasopressin, and other endocrine factors such as catecholamines and natriuretic peptides. The review also highlights the feedback loops and receptor sensitivities that sustain hypertensive states over time. Understanding these hormonal contributions is essential for identifying therapeutic targets and improving the management of hypertensive patients. Overall, the paper aims to provide a comprehensive view of how hormonal imbalance acts as a key driver in the pathogenesis of hypertension.

Mazkur maqolada maqom san’ati doirasida xonandaning ijro imkoniyatlarini to‘g‘ri baholash va samarali yo‘naltirishning nazariy va amaliy asoslari yoritiladi. Maqom asarlarining murakkab vokal tuzilmasi, ohangdorlik, frazalash, intonatsiya va badiiy ifoda jihatlari chuqur tahlil qilinib, xonandalarning vokal salohiyatini aniqlash, rivojlantirish va ijroga moslashtirish masalalari o‘rganiladi. Xususan, maqom xonandasi uchun zarur bo‘lgan vokal tayyorgarlik, nafas boshqaruvi, estetik tafakkur, psixofiziologik muvozanat va ijodiy yondashuvlar muhim omil sifatida ta’kidlanadi.

Ushbu maqolada XIX asr oxiri va XX asr boshlarida O‘rta Osiyoda yuzaga kelgan jadidchilik harakatining mazmun-mohiyati, tarixiy bosqichlari, asosiy g‘oyalari hamda bugungi kunda bu harakat merosining O‘zbekiston jamiyatidagi ahamiyati tahlil qilinadi. Jadidchilik harakatining asoschilari tomonidan ilgari surilgan ma’rifiy, ijtimoiy va siyosiy g‘oyalarning zamonaviy ta’lim tizimi, gender tengligi, milliy o‘zlikni anglash va fuqarolik jamiyati qurilishiga ta’siri yoritilgan. Shuningdek, jadid matbuoti, teatr va adabiy merosining yosh avlod tarbiyasidagi roli, bugungi islohotlar bilan o‘zaro bog‘liqligi chuqur o‘rganilgan. Maqolada tarixiy va zamonaviy qarashlar uyg‘unligi orqali jadidchilik harakatining dolzarbligi va bugungi kundagi o‘rni ilmiy asosda tahlil etiladi.

This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.