This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.

Ushbu maqolada XIX asr oxiri va XX asr boshlarida O‘rta Osiyoda yuzaga kelgan jadidchilik harakatining mazmun-mohiyati, tarixiy bosqichlari, asosiy g‘oyalari hamda bugungi kunda bu harakat merosining O‘zbekiston jamiyatidagi ahamiyati tahlil qilinadi. Jadidchilik harakatining asoschilari tomonidan ilgari surilgan ma’rifiy, ijtimoiy va siyosiy g‘oyalarning zamonaviy ta’lim tizimi, gender tengligi, milliy o‘zlikni anglash va fuqarolik jamiyati qurilishiga ta’siri yoritilgan. Shuningdek, jadid matbuoti, teatr va adabiy merosining yosh avlod tarbiyasidagi roli, bugungi islohotlar bilan o‘zaro bog‘liqligi chuqur o‘rganilgan. Maqolada tarixiy va zamonaviy qarashlar uyg‘unligi orqali jadidchilik harakatining dolzarbligi va bugungi kundagi o‘rni ilmiy asosda tahlil etiladi.

This article discusses the issues of managing energy sources in modern communication systems through adaptive control models to improve energy efficiency. The possibility of evaluating the energy supply state in real-time, considering the variability of the load and external factors, and developing optimal control strategies is analyzed.

В статье рассмотрен сновные трудности и стратегии перевода реалий в контексте художественного текста (на материале перевода поэм Максуда Шейхзаде), а также даны определения термина реалия.В статье рассмотрен сновные трудности и стратегии перевода реалий в контексте художественного текста (на материале перевода поэм Максуда Шейхзаде), а также даны определения термина реалия.

Usı maqalada psixologiyalıq keńes túsinigi, onıń mazmunı, ámeliy áhmiyeti hám de psixologiya pánindegi ózine tán mashqala sıpatında úyreniliwi jaritılǵan. Sonday-aq, másláhátlesiw procesiniń basqıshları, psixologiyalıq qatnaslar hám qarıydar menen islesiwde júzege keletuǵın qıyınshılıqlar da tallanǵan.