This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.

Surxon vohasida esa Sherobod, Denov, Boysun, Sarijo’y va Yurchi kabi bekliklar bo’lgan va bular turli davrlarda tashkil etilib yugatilib turilgan. Ushbu maqolada esa Surxon vohasining shimoliy qismida joylashgan bekliklarni tadqiq qilamiz.

This paper explores the physiological and pathophysiological responses of the human body to stress. Stress, defined as any challenge that disrupts homeostasis, triggers complex mechanisms involving the nervous, endocrine, and immune systems. Acute stress activates adaptive responses, such as the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, which prepare the body to handle immediate threats. However, chronic stress leads to sustained hormonal imbalances, immune suppression, and increased inflammation, contributing to various diseases including cardiovascular disorders, diabetes, and mental health issues. The dual nature of stress highlights the importance of effective management strategies to maintain health and prevent disease progression. This paper also discusses current understanding of stress-immune system interactions and suggests holistic approaches for stress reduction and health improvement.

Bul maqalada emocional sharshaw sindromı (burnout) túsinigi, onıń qáliplesiw sebepleri hám ásirese, sociallıq belsendilik penen baylanıslı júzege keletuǵın psixologiyalıq hám fiziologiyalıq qáwip-qáterler tallanǵan. Sonday-aq, sindromnıń aldın alıw boyınsha usınıslar da berilgen.

Mazkur maqolada sport tadbirlarida marketing strategiyalarining tutgan o‘rni, ularning qo‘llanilish shakllari va samaradorlik darajasi har tomonlama tahlil qilinadi. Sport sohasi zamonaviy jamiyatda nafaqat sog‘lom turmush tarzini targ‘ib qiluvchi ijtimoiy institut, balki katta iqtisodiy salohiyatga ega bo‘lgan tarmoq sifatida ham maydonga chiqmoqda. Xususan, yirik sport tadbirlarining muvaffaqiyatli tashkil etilishi ularning marketing jihatdan to‘g‘ri rejalashtirilganligiga bog‘liq. Maqolada sport marketingining asosiy strategiyalari — brending, raqamli marketing, homiylik aloqalari, auditoriya bilan ishlash va tomoshabinlar tajribasini boshqarish kabi yo‘nalishlar alohida ko‘rib chiqiladi.