This article explores the pathophysiological mechanisms underlying the development of hypertension, with a special emphasis on the hormonal factors that contribute to elevated blood pressure. Hypertension, one of the most prevalent cardiovascular disorders worldwide, results from a complex interplay between genetic predisposition, environmental influences, and dysregulation of multiple physiological systems. The article discusses how alterations in renal function, vascular resistance, and sympathetic nervous system activity lead to chronic elevation of arterial pressure. Particular attention is given to the renin-angiotensin-aldosterone system (RAAS), vasopressin, and other endocrine factors such as catecholamines and natriuretic peptides. The review also highlights the feedback loops and receptor sensitivities that sustain hypertensive states over time. Understanding these hormonal contributions is essential for identifying therapeutic targets and improving the management of hypertensive patients. Overall, the paper aims to provide a comprehensive view of how hormonal imbalance acts as a key driver in the pathogenesis of hypertension.

Mazkur maqolada jismoniy tarbiya va sport sohasida raqamli texnologiyalarning qo‘llanilishiga oid yangi tendensiyalar, ularning samaradorligi va imkoniyatlari tahlil qilinadi. Axborot-kommunikatsiya texnologiyalarining jadal rivojlanishi sport mashg‘ulotlarini takomillashtirish, sportchilarning salomatligini monitoring qilish, trening jarayonlarini optimallashtirish hamda sport tadbirlarini keng auditoriyaga yetkazishda muhim ahamiyat kasb etmoqda.

Bul maqalada emocional sharshaw sindromı (burnout) túsinigi, onıń qáliplesiw sebepleri hám ásirese, sociallıq belsendilik penen baylanıslı júzege keletuǵın psixologiyalıq hám fiziologiyalıq qáwip-qáterler tallanǵan. Sonday-aq, sindromnıń aldın alıw boyınsha usınıslar da berilgen.

Bugungi kunda jamiyatimizda axloqiy tarbiyaning kuchaytirilishi, yosh avlod qalbida ezgulik, mehr-oqibat, halollik kabi fazilatlarni singdirish muhim masalalardan biridir. Ayniqsa, boshlang‘ich ta’lim bosqichida bolalarning ijtimoiy ongini shakllantirish orqali ularni jamiyatga foydali shaxs etib voyaga yetkazish mumkin. Bu borada tasavvuf ta’limotining tarbiyaviy jihatlari alohida ahamiyat kasb etadi. Tasavvuf insonni ichki poklanishga, boshqalarga nisbatan mehribonlik va muruvvat bilan munosabatda bo‘lishga chorlaydi. Ushbu maqolada tasavvuf ta’limotining boshlang‘ich sinf o‘quvchilari ongiga ijtimoiy g‘oyalarni singdirishdagi ahamiyati yoritiladi. Har bir inson yoshlik chog’idan boshlab odob axloq qoidalariga rioya qilishi va atrofdagilarga ham hurmatda bo’lishi zarur. Hozirgi globallashuv jarayonida o’quvchilarni ijtimoiy ongini rivojlantirish juda muhim jarayon hisoblanadi.

This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.