International scientific journal "Modern Science and Research"

ISSN: 2181-3906;   OAV Guvohnoma №042359;   Impact factor (UIF-2022): 8.2
Ushbu jurnalda O'zbekiston va chet davlatlar olimlari ilmiy maqolalari chop etiladi.
Ushbu jurnal OAK ro'yxatida mavjud xalqaro bazalarda indekslanib, elektron va bosma holatda nashr etib boriladi.
Jurnalning rasmiy tillari: o‘zbek, rus, ingliz
Jurnal telegram kanali: https://t.me/modernscience_research
Maqola muallifiga BEPUL qabul qilinganlik haqida tabriknoma, sertifikat, indekslanganligi haqida ma'lumotnoma va mualliflik guvohnomasi beriladi.
Jurnal har oyda nashr qilinadi.
Maqolalar yuborish uchun: @modernscience_research
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Articles Information letter

Oxirgi qushilgan maqolalar:



JISMONIY TARBIYA VA SPORT SOHASIDA RAQAMLI TEXNOLOGIYALARNI QO'LLASHNING YANGI TENDENSIYALARI

Mazkur maqolada jismoniy tarbiya va sport sohasida raqamli texnologiyalarning qo‘llanilishiga oid yangi tendensiyalar, ularning samaradorligi va imkoniyatlari tahlil qilinadi. Axborot-kommunikatsiya texnologiyalarining jadal rivojlanishi sport mashg‘ulotlarini takomillashtirish, sportchilarning salomatligini monitoring qilish, trening jarayonlarini optimallashtirish hamda sport tadbirlarini keng auditoriyaga yetkazishda muhim ahamiyat kasb etmoqda.


20.05.2025 Volume 4 Issue 5 View more Download
EMOCIONAL SHARSHAW SINDROMI HÁM SOCIALLIQ BELSENDILIK PENEN BAYLANISLI QÁWIP-QÁTERLER

Bul maqalada emocional sharshaw sindromı (burnout) túsinigi, onıń qáliplesiw sebepleri hám ásirese, sociallıq belsendilik penen baylanıslı júzege keletuǵın psixologiyalıq hám fiziologiyalıq qáwip-qáterler tallanǵan. Sonday-aq, sindromnıń aldın alıw boyınsha usınıslar da berilgen.


20.05.2025 Volume 4 Issue 5 View more Download
PATHOPHYSIOLOGICAL BASIS AND HORMONAL FACTORS OF THE DEVELOPMENT OF HYPERTENSION

This article explores the pathophysiological mechanisms underlying the development of hypertension, with a special emphasis on the hormonal factors that contribute to elevated blood pressure. Hypertension, one of the most prevalent cardiovascular disorders worldwide, results from a complex interplay between genetic predisposition, environmental influences, and dysregulation of multiple physiological systems. The article discusses how alterations in renal function, vascular resistance, and sympathetic nervous system activity lead to chronic elevation of arterial pressure. Particular attention is given to the renin-angiotensin-aldosterone system (RAAS), vasopressin, and other endocrine factors such as catecholamines and natriuretic peptides. The review also highlights the feedback loops and receptor sensitivities that sustain hypertensive states over time. Understanding these hormonal contributions is essential for identifying therapeutic targets and improving the management of hypertensive patients. Overall, the paper aims to provide a comprehensive view of how hormonal imbalance acts as a key driver in the pathogenesis of hypertension.


20.05.2025 Volume 4 Issue 5 View more Download
PATHOPHYSIOLOGY OF AUTOIMMUNE DISEASES MECHANISMS OF IMMUNE TOLERANCE DISRUPTION

This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.


20.05.2025 Volume 4 Issue 5 View more Download
PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL REACTIONS OF THE ORGANISM UNDER STRESS

This paper explores the physiological and pathophysiological responses of the human body to stress. Stress, defined as any challenge that disrupts homeostasis, triggers complex mechanisms involving the nervous, endocrine, and immune systems. Acute stress activates adaptive responses, such as the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, which prepare the body to handle immediate threats. However, chronic stress leads to sustained hormonal imbalances, immune suppression, and increased inflammation, contributing to various diseases including cardiovascular disorders, diabetes, and mental health issues. The dual nature of stress highlights the importance of effective management strategies to maintain health and prevent disease progression. This paper also discusses current understanding of stress-immune system interactions and suggests holistic approaches for stress reduction and health improvement.


20.05.2025 Volume 4 Issue 5 View more Download
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