This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.

Emocional sharshaw - bul uzaq dawam etken stress, emocional hám fizikalıq artıqsha júklemeler nátiyjesinde insannıń ruwxiy resurslarınıń tawsılıwı hám sharshaw jaģdayı. Bul maqalada sezimlik sharshawdıń aqıbetleri hám onıń insan organizmine bolǵan qáwip-qáterleri tallanǵan. Maqalada sezimlik sharshawdıń psixologiyalıq, fizikalıq, sociallıq hám kásiplik tarawlardaǵı unamsız tásirleri hám olardı azaytıwdıń nátiyjeli usılları sáwlelendirilgen. Maqala sezimlik sharshawdıń uzaq múddetli aqıbetlerinen saqlanıw hám olardı saplastırıw boyınsha usınıslardı usınadı.

This article discusses the issues of managing energy sources in modern communication systems through adaptive control models to improve energy efficiency. The possibility of evaluating the energy supply state in real-time, considering the variability of the load and external factors, and developing optimal control strategies is analyzed.

Mazkur maqolada jismoniy tarbiya va sport sohasida raqamli texnologiyalarning qo‘llanilishiga oid yangi tendensiyalar, ularning samaradorligi va imkoniyatlari tahlil qilinadi. Axborot-kommunikatsiya texnologiyalarining jadal rivojlanishi sport mashg‘ulotlarini takomillashtirish, sportchilarning salomatligini monitoring qilish, trening jarayonlarini optimallashtirish hamda sport tadbirlarini keng auditoriyaga yetkazishda muhim ahamiyat kasb etmoqda.

Agar kishi biror bir og‘ir ishni bajarayotgan bo‘lsa, u birmuncha vaqtdan so‘ng bu ishni bajarish tobora qiynlashib borayotganini sezadi. Chetdan qaraganda bu kishining holati ancha o‘zgarganligini ko‘rish mumkin. Bu o‘zgarishni mimika muskullari kuchlanishida, ter paydo bo‘lishida kurish mumkin.ayni vaqtda uning organizmida bimruncha jiddiy fiziologik o‘zgarishlar ham ro‘y beradi. Qiyinchiliklar ko‘payib borishiga karamsdan, kishi iroda kuchi hisobiga dastlabki ish shiddati birmuncha vaqt saqlab turishi mumkin.