This article explores the complex pathophysiology of autoimmune diseases with a primary focus on the mechanisms underlying the breakdown of immune tolerance. Immune tolerance is essential for preventing the immune system from attacking the body’s own tissues. The review covers both central and peripheral tolerance processes, highlighting how genetic predispositions, environmental factors, and immune regulatory failures contribute to the development of autoimmunity. Key cellular players, such as regulatory T cells and antigen-presenting cells, are discussed in relation to their roles in maintaining immune homeostasis. Additionally, the article examines current understanding of molecular mimicry, epitope spreading, and other pathogenic mechanisms leading to self-reactivity. The challenges in diagnosis and treatment of autoimmune diseases are also addressed, emphasizing the need for targeted therapeutic approaches aimed at restoring immune tolerance rather than merely suppressing immune responses.

Mazkur maqola, toshkent viloyаti xаlq xo‘jаligidа temir yo‘llаr tizimining o‘rni mavzusida yozilgan. Ushbu maqolada, toshkent viloyаti xаlq xo‘jаligidа temir yo‘llаr tizimining o‘rni va xususiyatlari o‘rganilgan. Maqolada toshkent viloyаti xаlq xo‘jаligidа temir yo‘llаr tizimining o‘rni samarali bo‘lishi va ularning yuqori natijalarga erishishi uchun qanday shart-sharoitlar zarurligi tahlil qilingan.

This paper explores the physiological and pathophysiological responses of the human body to stress. Stress, defined as any challenge that disrupts homeostasis, triggers complex mechanisms involving the nervous, endocrine, and immune systems. Acute stress activates adaptive responses, such as the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, which prepare the body to handle immediate threats. However, chronic stress leads to sustained hormonal imbalances, immune suppression, and increased inflammation, contributing to various diseases including cardiovascular disorders, diabetes, and mental health issues. The dual nature of stress highlights the importance of effective management strategies to maintain health and prevent disease progression. This paper also discusses current understanding of stress-immune system interactions and suggests holistic approaches for stress reduction and health improvement.

This paper explores the pathophysiological basis of metabolic disturbances in diabetes mellitus, a chronic disorder characterized by impaired insulin secretion and action. It examines the complex mechanisms underlying hyperglycemia, insulin resistance, and altered metabolism of carbohydrates, lipids, and proteins. The study highlights how these metabolic imbalances contribute to the development of diabetic complications such as neuropathy, nephropathy, and cardiovascular diseases. Understanding these fundamental processes is essential for advancing treatment strategies and improving patient outcomes. The paper also discusses current therapeutic approaches aimed at restoring metabolic balance and preventing long-term damage.

Mazkur maqolada dinning jamiyatdagi ijtimoiy funksiyalari, axloqiy-me’yoriy qadriyatlarni shakllantirishdagi roli va insonlar o‘rtasidagi ijtimoiy munosabatlarni mustahkamlashdagi ahamiyati tahlil qilinadi. Tarixiy va zamonaviy kontekstda dinning jamiyatdagi o‘rniga baho beriladi, ayniqsa, Islom dini doirasida ijtimoiy barqarorlik, axloqiy poklik va ijtimoiy mas’uliyat masalalariga e’tibor qaratiladi. Din faqat ibodat emas, balki inson va jamiyat o‘rtasidagi ko‘prik vazifasini bajaruvchi omil sifatida yoritiladi.