This article explores the complex pathophysiological mechanisms underlying the development of kidney failure. It highlights the key roles of hemodynamic changes, cellular injury, inflammation, oxidative stress, and hormonal imbalances in the progression of renal dysfunction. The chronic activation of the renin-angiotensin-aldosterone system and its contribution to fibrosis and nephron loss are discussed in detail. The article also examines how inflammatory processes and oxidative damage exacerbate kidney tissue injury, while hormonal disturbances contribute to systemic complications such as anemia and mineral imbalance. Emphasis is placed on the importance of early detection and targeted treatment strategies to slow disease progression and improve patient outcomes. The review concludes with a discussion on future research directions aimed at developing novel diagnostic markers and therapeutic approaches for kidney failure.

This paper explores the physiological and pathophysiological responses of the human body to stress. Stress, defined as any challenge that disrupts homeostasis, triggers complex mechanisms involving the nervous, endocrine, and immune systems. Acute stress activates adaptive responses, such as the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, which prepare the body to handle immediate threats. However, chronic stress leads to sustained hormonal imbalances, immune suppression, and increased inflammation, contributing to various diseases including cardiovascular disorders, diabetes, and mental health issues. The dual nature of stress highlights the importance of effective management strategies to maintain health and prevent disease progression. This paper also discusses current understanding of stress-immune system interactions and suggests holistic approaches for stress reduction and health improvement.

Bul maqalada emocional sharshaw sindromı (burnout) túsinigi, onıń qáliplesiw sebepleri hám ásirese, sociallıq belsendilik penen baylanıslı júzege keletuǵın psixologiyalıq hám fiziologiyalıq qáwip-qáterler tallanǵan. Sonday-aq, sindromnıń aldın alıw boyınsha usınıslar da berilgen.

Bul maqalada oqiwshilardiń óz-ózin bahalaw dárejesi menen olardiń oqiw iskerligindegi jetiskenlik ortasindaǵi psixologik baylanis analiz etiledi. Izertlewde ‘’óz- ózin bahalaw’’ tu’siniginiń mazmuni, qáliplesiw faktorlari hám oniń oqiw processindegi áhmiyeti aship beriledi. Sonday-aq óz-ózin joqari dárejede bahalawshi oqiwshilardiń ózlestiriw kórsetkishleri joqari boliwi, pás bahalawshi oqiwshilar ese oqiw iskerliginde isenimsizlik penen ajralip turiwi kórsetilgen.

Mazkur maqolada maqom san’ati doirasida xonandaning ijro imkoniyatlarini to‘g‘ri baholash va samarali yo‘naltirishning nazariy va amaliy asoslari yoritiladi. Maqom asarlarining murakkab vokal tuzilmasi, ohangdorlik, frazalash, intonatsiya va badiiy ifoda jihatlari chuqur tahlil qilinib, xonandalarning vokal salohiyatini aniqlash, rivojlantirish va ijroga moslashtirish masalalari o‘rganiladi. Xususan, maqom xonandasi uchun zarur bo‘lgan vokal tayyorgarlik, nafas boshqaruvi, estetik tafakkur, psixofiziologik muvozanat va ijodiy yondashuvlar muhim omil sifatida ta’kidlanadi.