This study examines the development of antibiotic resistance in Helicobacter pylori infection and its influence on the effectiveness of eradication therapy. The clinical factors associated with treatment failure, including previous antibiotic exposure, treatment adherence, and the possible presence of antimicrobial resistance, were considered. The study also describes the molecular mechanisms of resistance and the role of microbiological and molecular diagnostic methods in identifying resistant strains. The results indicate that previous use of antibiotics, particularly macrolides and fluoroquinolones, may be associated with reduced eradication effectiveness. The study emphasizes the importance of rational antibiotic selection, individualized treatment approaches, appropriate diagnostic assessment, adherence to prescribed therapy, and confirmation of eradication after treatment. These approaches may contribute to improving therapeutic outcomes and reducing the clinical impact of antibiotic-resistant Helicobacter pylori infection.

This study evaluates modern approaches to the diagnosis and treatment of ischemic heart disease in patients identified in the Fergana region. Particular attention is given to the clinical characteristics of patients, major cardiovascular risk factors, diagnostic findings, pharmacological treatment, and the use of revascularization procedures in selected cases. The study considers the role of electrocardiography, echocardiography, coronary imaging, and individualized medical therapy in the management of ischemic heart disease. The clinical effectiveness of treatment is assessed through changes in anginal symptoms, exercise tolerance, functional status, and the need for repeated cardiovascular care. The findings highlight the importance of combining early risk assessment, modern diagnostic technologies, evidence-based pharmacological treatment, appropriate revascularization, and long-term follow-up in improving cardiovascular care.

This article examines modern approaches to predicting the development of preeclampsia and implementing preventive measures in pregnant women with chronic pyelonephritis. The study assessed the clinical significance of maternal blood pressure, urinary protein levels, renal function, recurrent urinary tract infections, and fetal-placental monitoring during pregnancy. The findings indicate that recurrent urinary tract infections, deterioration of renal function, proteinuria, and progressive elevation of blood pressure may be associated with an increased risk of preeclampsia in pregnant women with chronic pyelonephritis. Individual risk stratification and regular antenatal monitoring may contribute to earlier identification of high-risk patients and timely implementation of preventive and therapeutic measures. Continuous assessment of maternal renal status and fetal-placental condition is particularly important for reducing the risk of maternal and perinatal complications. The results support an individualized approach to the management of pregnancy complicated by chronic pyelonephritis and emphasize the importance of early risk assessment and systematic maternal-fetal surveillance.

Uterine fibroids are among the most common benign gynecological diseases in women of reproductive age and may affect the course of pregnancy, delivery, and perinatal outcomes. The aim of this study was to evaluate the course of pregnancy in women with uterine fibroids and to identify the main obstetric and perinatal complications. The study assessed clinical and anamnestic characteristics, size, number, and localization of fibroid nodes, pregnancy-related symptoms, delivery outcomes, and neonatal indicators. The results showed that larger and multiple fibroid nodes were more frequently associated with pelvic pain, increased uterine tone, abnormal fetal presentation, preterm delivery, cesarean delivery, and postpartum hemorrhage. Low birth weight and the need for neonatal observation were also observed among newborns. The findings indicate that the size, number, and localization of uterine fibroids should be considered when assessing pregnancy risk. Individualized clinical and ultrasound monitoring may contribute to the early detection of complications and improve the management of pregnancy and perinatal outcomes.

Ushbu maqolada XX asr boshlarida o‘zbek adabiyotida yuzaga kelgan janriy yangiliklar hamda ularning shakllanishida jadid adabiyotining tutgan o‘rni ilmiy-nazariy jihatdan tahlil qilinadi. Xususan, she’riyatda barmoq vaznining keng qo‘llanilishi, nasrda hikoya, qissa va roman janrlarining shakllanishi, publitsistik yo‘nalishning rivojlanishi hamda dramaturgiyaning vujudga kelishi jarayonlari yoritiladi. Shuningdek, jadid ma’rifatparvarlarining milliy adabiyot taraqqiyotiga qo‘shgan hissasi, ularning yangi adabiy janr va shakllarni rivojlantirishdagi faoliyati hamda ijodiy izlanishlari tahlil qilinadi. Jadid adabiyotida ilgari surilgan ma’rifat, milliy uyg‘onish, taraqqiyot va ijtimoiy ongni yuksaltirish g‘oyalarining adabiy jarayonga ta’siri ochib beriladi. Maqolada jadid adabiyotida shakllangan badiiy-estetik tamoyillarning keyingi davr, xususan, hozirgi o‘zbek adabiyotidagi janriy izlanishlarga ta’siri ham ko‘rib chiqiladi. Tadqiqot natijasida jadid adabiyoti o‘zbek milliy adabiyotining yangilanishi va zamonaviy janrlar tizimining shakllanishida muhim adabiy-tarixiy omil bo‘lgani asoslab beriladi.