Abstract. Malabsorption syndrome is a multifactorial clinical condition characterized by impaired digestion and absorption of nutrients in the small intestine. The disorder may arise from congenital enzyme deficiencies, chronic inflammatory diseases, pancreatic and hepatobiliary dysfunction, infectious agents, or structural intestinal abnormalities. Pathomorphological changes, such as villous atrophy, crypt hyperplasia, and inflammatory infiltration of the mucosa, are central to its development and progression. Clinically, malabsorption presents with both gastrointestinal symptoms, including chronic diarrhea, abdominal discomfort, and steatorrhea, as well as systemic manifestations such as anemia, bone demineralization, growth retardation, and neurological deficits. Diagnosis requires an integrated approach, combining biochemical, radiological, endoscopic, and histopathological evaluations.