Abstract. This article presents an overview of advanced technologies utilizing synthesized nanoparticles for the selective separation and purification of crude oil. The growing demand for cleaner fuels and more efficient refining methods has driven the development of nanotechnology-based solutions in the petroleum industry. Engineered nanoparticles, including metal oxides, carbon-based nanostructures, and functionalized silica, have demonstrated exceptional selectivity, surface reactivity, and stability under harsh processing conditions. The study highlights the mechanisms by which nanoparticles interact with crude oil components—such as asphaltenes, resins, and sulfur-containing compounds—enabling targeted removal and separation. Laboratory-scale experiments and pilot-scale applications are analyzed to assess improvements in phase separation, emulsion breaking, and reduction of processing time and energy consumption. The results support the feasibility of integrating nanoparticle-based systems into conventional refining processes to enhance performance, reduce environmental impact, and increase the yield of high-value fractions. These technologies show strong potential for contributing to the future of sustainable and efficient crude oil treatment.