Abstract. Antibiotic resistance in pneumonia is an escalating global health concern that undermines the effectiveness of current treatments and increases morbidity and mortality rates. This paper reviews the key mechanisms by which bacteria develop resistance to commonly used antibiotics, including enzymatic drug degradation, target site modification, and efflux pumps. The impact of resistant pathogens on clinical outcomes, treatment strategies, and healthcare systems is discussed. Emphasis is placed on the importance of antibiotic stewardship programs, vaccination, and rapid diagnostic techniques in managing resistant infections. The review also highlights ongoing research into novel therapeutics and the need for coordinated global efforts to mitigate antibiotic resistance. Effective management of antibiotic resistance in pneumonia is critical for improving patient outcomes and safeguarding public health.