Abstract. Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels resulting from defects in insulin secretion, insulin action, or both. Despite the availability of various therapeutic options, managing diabetes remains a significant challenge due to disease complexity and the risk of associated complications. Recent advances in diabetes treatment have introduced novel pharmacological agents, such as sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists, which provide improved glycemic control and offer cardiovascular and renal protective effects. Additionally, innovations in insulin delivery systems, including continuous glucose monitoring and artificial pancreas devices, have enhanced the precision and convenience of insulin therapy. Emerging regenerative medicine approaches, such as stem cell therapy and islet transplantation, show promising potential for restoring endogenous insulin production and achieving long-term remission.