Abstract. Chronic prostatitis (CP) is a multifactorial urological condition that significantly impacts male health, causing considerable morbidity. The pathogenesis of chronic prostatitis is complex and multifaceted, involving a combination of infectious, autoimmune, inflammatory, and neurological factors. Accurate diagnosis and effective management remain challenging due to the heterogeneous nature of the condition and its overlap with other urological and non-urological diseases. This study aims to provide a comprehensive review of modern diagnostic methods, including clinical, laboratory, and imaging approaches, along with pharmacological and non-pharmacological treatment strategies. We also present the results of a cohort study involving 120 patients with chronic prostatitis, analyzing the effectiveness of various treatment modalities. Our findings highlight the importance of a personalized, multidisciplinary approach in managing chronic prostatitis to improve patient outcomes.