Abstract. In our study, we examined white laboratory rats born to control and experimental mothers with hypothyroidism. Morphological analysis of the pancreas during various stages of postnatal ontogenesis revealed significant delays in the development and formation of individual components of the vascular wall compared to the control group. From the first days of the experiment, changes in the arterial wall were observed in all experimental animals. The results demonstrate that morphological changes in pancreatic cells and their blood vessels occur in offspring born to mothers with hypothyroidism.