Abstract. This article examines the role of inflammation and immunological mechanisms in myocardial infarction. The results of the study show that inflammation and the immune response in the process of myocardial infarction are a complex, multi-stage process. The inflammatory reaction affects tissue damage in the infarct zone and the remodeling of the heart muscle. At the initial stage, mediators released from damaged cells activate the immune system, which can enhance the processes of necrosis and fibrosis. The immunological response also plays an important role in the cleansing and regeneration of the myocardial infarction site, but excessive inflammation and immune response can increase the risk of heart failure.