Abstract. Ischemic heart disease is one of the main causes of disability and death among the population all over the world, including in Uzbekistan. Among the comorbid conditions observed in this group of patients, kidney dysfunction is of particular importance, and even the earliest subclinical disorder affects the exacerbation of the main disease and the development of complications, as well as mortality rates as an independent risk factor. This article aims to investigate the significance of creatinine, cystatin C, proteinuria and podocyturia in early diagnosis of RD in patients with stable angina pectoris and their association with cardiovascular risk. Cystatin C has been reported to be reliably effective compared to serum creatinine in the early diagnosis of RD in patients with stable angina pectoris. It has also been confirmed that podocyturia is one of the main markers for its early detection and assessment of its progression.