Abstract. Lipoprotein metabolism refers to the process of transporting fats and proteins in the human body, and this process is of great importance for cardiovascular health. Regular blood donors may differ in their blood profiles from the general population, so studying their lipoprotein metabolism will help to better understand issues related to cardiovascular health and disease. This study will examine the lipoprotein metabolism of blood donors and its impact on health, aiming to determine the changes in lipid profiles among donors and their relationship to heart health. According to some data, regular blood donation is associated with a decrease in lipid profiles. Lipid profile assessment is an accepted method of assessing a person's risk for coronary heart disease, especially if there is evidence of lipid peroxidation. Regular blood donation can reduce iron stores, which in turn reduces lipid peroxidation. This study was conducted to determine the effect of blood donation on lipid profiles.