Abstract. The development of primary open-angle glaucoma (POAG) is currently considered to be a chain of interaction between etiological and pathogenetic factors, among which the leading role is played by genetic predisposition, general changes, ischemia, primary local functional and dystrophic changes, disturbances in hydrostatics and hydrodynamics of the eye, increased intraocular pressure, vascular disorders, dystrophy and tissue degeneration. Purpose. The purpose of this study is to study the factors of endothelial dysfunction leading to a decrease in ocular hemoperfusion in patients with primary open-angle glaucoma. Methods. The study included 92 patients with POAG, aged 65 to 80 years. The level of lipid peroxidation and AOS, the lipid composition of the blood and the indicators of the complement system were studied before and after treatment. Conclusion. The study of indicators of oxidative stress and antioxidant status of blood serum according to the corresponding levels (high, medium and low) makes it possible to determine the risk of disease progression and evaluate the effectiveness of treatment in patients with POAG.