Abstract. In recent years, there has been a trend in all developed countries of the world for the rapid spread of the combined consumption of psychoactive substances, the market of which is increasingly expanding due to the emergence of new synthetic drugs and drugs. Cases of the appearance of intoxicating psychoses as a result of the combined use of psychoactive substances of various pharmacological groups have become significantly more frequent, they are practically not found in the mono-consumption of classical opioids, and rarely occur with an overdose of natural cannabinoids