Abstract. This work studies the similarities and differences between the grammar of English and Uzbek in a comparative manner. Particular attention is paid to the word classes, sentence structure, tense system, word order, and verb forms of both languages. The analytical structure of English and the agglutinative features of Uzbek are analyzed by comparison using examples. Grammatical problems encountered in the translation process and ways to overcome them are also considered. This work may be useful for language learners, translators, and linguists.